The Relationship Between Blood Lead Levels and Clinical Features Among Multiple Sclerosis Patients in Isfahan, Iran
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 448
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شناسه ملی سند علمی:
JR_IJHSE-3-1_002
تاریخ نمایه سازی: 4 خرداد 1395
چکیده مقاله:
Lead (Pb) is one of the most likely toxicants that could be potentially a risk factor in the development of Multiple Sclerosis (MS) through changes in the immune system. The purpose of the study was to describe the clinical features of MS in general and for sub-groups stratified for gender, age, residence, disease duration, disability degree, clinical diagnosis in Isfahan, Iran and also, to elucidate the relationship between the blood Pb level and the development of MS. Blood samples of 48 patients (20 to 57 years) were selected from the department of neurology of the Kashani hospital in Isfahan, Iran and were analyzed for Pb using anodic stripping voltammetry (ASV). The clinical and demographic characteristics in our study were similar to those in other reports. The blood Pb level in 70.83% of the total population was <20 μg/l. No statistically significant difference was observed between the Pb level and some patient characteristics. These findings did not support the assumption that Pb could be a pathogenetic factor in MS. However, the exposure to a large amount of Pb can increase the risk of developing MS. Obviously; more investigation is needed to investigate the contribution of Pb to the development of MS.
کلیدواژه ها:
Multiple sclerosis (MS) ، Blood ، Lead (Pb) ، Anodic Stripping Voltammetry (ASV) ، IsfahanLIST OF ABBREVIATIONS
نویسندگان
Zahra Razavi
Department of Natural Resources, Isfahan University of Technology, Isfahan 8415683111, Iran
Mojtaba Jokar
Department of Natural Resources, Isfahan University of Technology, Isfahan 8415683111, Iran
Alireza Allafchian
Nanotechnology and Advanced Materials Institute, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Zahra Hossinpour
Department of Natural Resources, Isfahan University of Technology, Isfahan 8415683111, Iran