Is there any correlation between embryo morphokinetics development and maternal age in an intra-cytoplasmic sperm injection program
محل انتشار: هشتمین کنگره بین المللی و جشنواره دانشجویی طب تولید مثل و سومین کنگره بین المللی ژنتیک تولید مثل
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 374
نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
این مقاله در بخشهای موضوعی زیر دسته بندی شده است:
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
RMED08_149
تاریخ نمایه سازی: 21 مرداد 1398
چکیده مقاله:
Background: It is widely accepted that aging decreases the fertility capacity in women.Objective: The aim of this study was to assess embryo morphokinetics parameters and cleavage pattern correlation with maternal age.Materials and Methods: Morphokinetics of embryos derived from women <30, 30-35, 35-40 and 40≤yr were compared retrospectively in terms of time of second PB extrusion (tPB2), time of pronuclei appearance (tPNa), time of pronuclei fading (tPNf) and time of two to eight discrete cells (t2-t8). Also, abnormal cleavage patterns such as, uneven blastomeres at two cells stage, cell fusion (Fu) and Trichotomous Mitoses (TM) were assessed.Results: The findings showed that only t5 occurred later in women 35-40 and 40≤ when compared with <30 and 30-35 yr (p=0.000). Other morphokinetics timing parameters as well as uneven blastomere were comparable (p> 0.05). However, Fu and TM were increased in women with 40≤ age compared with younger women (p=0.000).Conclusion: It is concluded that maternal age correlated to cleavage pattern of embryos. So, evaluation of embryo morphokinetics may improve embryo selection and increase fertility in advanced maternal age.
کلیدواژه ها:
نویسندگان
A Faramarzi
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran- Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
MA Khalili
Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran