HN-02310228_ Effect of high dose vitamin D supplementation on antibody titres to heat shock protein 27 in adolescent girls

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 318

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شناسه ملی سند علمی:

ICNC03_139

تاریخ نمایه سازی: 12 اسفند 1398

چکیده مقاله:

Objective: Although vitamin D deficiency is associated with several inflammatory conditions, there have been few studies on the effects of vitamin D supplementation on markers of oxidative stress and inflammation. The aim of the current study was to evaluate the effects of high dose vitamin D supplementation on heat shock protein 27 antibody (anti-Hsp27) titres in adolescent girls.Methods: Five hundred and fifty adolescent girls received vitamin D3 at a dose of 50,000 IU/week for 9 weeks. Demographic, clinical, biochemical markers including serum fasting blood glucose, lipid profile and anti-Hsp27 titers as well as hematological parameters including white blood cell count (WBC), and red blood cell distribution width (RDW) were determined in all the subjects at baseline and at the end of the study. Results: Serum vitamin D increased significantly, from 6.4 (4.2-9.6) ng/mL to 35.6 (25.8-47.5) ng/mL (P <0.001) following the intervention. Furthermore, serum anti-Hsp27 titers were significantly lower after the 9-week vitamin D administration period [0.22(0.12-0.33) OD vs. 0.19(0.11-0.31) OD; P=0.002]. A significant correlation was found between serum anti-Hsp27 and RDW (r=0.13, p=0.037). The reduction in RDW values after intervention was particularly evident in subjects with the greatest increase in serum vitamin D levels.Conclusions: High-dose vitamin D supplementation was found to reduce antibody titers to Hsp 27. Further randomized placebo-controlled trials are warranted to determine the long time effect of vitamin D administration on the inflammatory process especially that associated with chronic disease.

نویسندگان

Zahra Khorasanchi

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Afsane Bahrami

Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran

Zahra Dehnavi

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Andishe Norouzian

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Shima Tavallaee

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran