Study the effect of milnacipran on neuropathic pain induced by cisplatin in mice

Background and Aim : cisplatin is used as an antineoplastic agent to treat solid tumor. However, it significantly develops peripheral neuropathy (dose-limiting side effect). In this study we investigated the effect of milnacipran on cisplatin-induced neuropathic pain in mice.Methods : Cisplatin was injected intra-peritoneally (2.3 mg/kg) once per day for 5 days followed by 5 days of rest for 2 cycles. Mice received milnacipran, intraperitoneally (i.p., 20 mg/kg) every day for 15 consecutive days. Naloxone was administered to evaluate milnacipran’s mechanism of action. Withdrawal response to thermal stimulation was measured to evaluate allodynia and hyperalgesia with hot plate and tail flick tests.Results : Repeated injection of cisplatin significantly induced neuropathic pain. Milnacipran at the dose of 20 mg/kg demonstrated analgesic effect in a significant manner. So that, milnacipran caused an increase in time latency when it was co-administered with cisplatin. Additionally, intra-peritoneal coadministration of naloxone with milnacipran did not suppressed the analgesic effect of milnacipran.Conclusion : The result of this study indicated that consecutive intra-peritoneal administration of milnacipran produces analgesic effect in chemotherapy-induced neuropathic pain. The author suggests the milnacipran as a promising treatment for chemotherapy-induced neuropathic pain. However, more experimental and clinical trial is needed to address this issue.

کلیدواژه ها:

milnacipran ، cisplatin ، neuropathic pain