Study of Antibacterial Activity Medicinal Plants in the Treatment of Helicobacter Pylori Infections

Helicobacter pylori (H. pylori) is one of the most common worldwide human infections. It is estimated over half of the Earth’s population are infected with this bacterium. This pathogen is a causative agent for many gastroduodenal diseases, peptic ulcers and gastric cancer. In recent years, emerging resistant to antibiotics limits their use in the treatment of this infection. However, eradication is not always successful and the use of these antibiotics occasionally causes emergence of resistant clones and various harmful adverse effects. Thus, development of new effective therapeutic agents could represent a significant advance in treatment of these infections. Traditional uses of plants for medicinal purposes provide a basis for the use of specific plants for specific medical conditions. In fact, a number of drugs and natural substances such as various essential oils, extracts of the lichen Certaria islandica, Chinese green tea and several native Iranian plants have been shown to have in vitro antibacterial activity against H. pylori. This study is a systematic review based on internal databases including SID, Iranmeddex, Magiran and authentic English databases including Scopus, PubMed, as well as articles and reviewed the letters that have met the inclusion criteria, were examined. As a result, many natural products have been studied to find new effective alternative drugs against difficult to treat H. pylori giving special attention to plants used traditionally for a long time against gastrointestinal disorders. This review presents the potential of many medicinal plants to serve as promising sources for new and alternative anti-H. pylori agents. As reviewed in this paper, it is obviously, there are numerous traditional plants potentially valuable sources of novel anti-H.pylori agents. However, most reports are on crud extracts, which gives general evaluation on the potency of these plants as anti-H. pylori agents but do not provide enough data on the complexity of these natural products to serve as drugs as well as the in vivo clinical studies.

کلیدواژه ها:

Medicinal plants ، Anti-bacterial activity ، Helicobacter pylori.