Using Personalized Medicine for Controlling Herpes: A new paradigm for an old disease

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 357

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شناسه ملی سند علمی:

IPMCMED01_069

تاریخ نمایه سازی: 23 آذر 1397

چکیده مقاله:

Every person has a unique variation of the human genome. Although most of the variation between individuals has no effect on health, an individual health stems from genetic background with behaviors and influences from the environment. One way that biological variation manifests itself is responsiveness to infections such as virals. In the meantime, herpes virus infections have enormous effects on almost every parts of the body. Herpes never goes away. Rather, the virus retreats to specific nerve roots, where it can be dormant for long periods of time. They even can be easily resulted in a drastic cancer. When it re-emerges, it travels up the same nerve root and causes lesions, usually in the same area as before. Stress and changes in immune function are known factors in determining re-emergence, but it may occur for no apparent reason. Many people have antibodies to HSV-1. This means that they have been exposed, but may have never had a cold sore (or they may have and it went away). For HSV-2, that number is lesser but even high particularly in Iran. As we know the frequency of recurrence of herpetic lesions is different between individuals. Besides, there is a meaningful difference between those individual infected reactively with herpes viruses that overtake by some kind of cancers afterwards and the others who have a less reactive infection. Due to the latency phenomenon of these viruses, it is proposed that this could be a real personal issue for every individual. On the other hand, the persons with a specific genetic makeup may have less severity, reactivity and therefore less probability for sliding to a cancer while the others are different. The aim of current projects should be mainly focused on the related interventional genes which may have prominent effects of the herpes virus latency in various people.

نویسندگان

Kaveh Haratian

Department of Microbiology and Immunology, Alborz University of Medical Sciences, Karaj - Iran