The relationship between insulin resistance and serum oxytocin level among infertile PCOS women

Background: The aim of this study is to compare oxytocin levels between PCOS and non PCOS infertile women and evaluate the relationship between insulin resistances (IR) and oxytocin level in infertile PCOS women.Methods: 161 infertile women of 20-35 years old entered this cross-sectional study. Eighty women with PCOS according to 2003 Rotterdam criteria and 81 ones did not have PCOS. FBS, fasting insulin (FI), 75gr oral glucose tolerance test (OGTT) were measured. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated and HOMA ≥2.5 was indicative of IR. The two groups were compared for their IR with serum oxytocin levels.Result: The mean oxytocin level in patients with PCOS was 124.94 ±40.98ng/l vs 207.42±108.7 ng/l for the non-PCOS group (p≤0.001). Correlation between HOMA-IR and oxytocin hormone was reverse and statistically significant overall (P=0.009, r= - 0.204) but in PCOS group was not significant (P=0.817, r= - 0.026). The mean FI, 2hr PP insulin and HOMA-IR were higher in PCOS group than in control group (13.52±11.12 μiu/mL vs 8.34±3.90 μiu/mL, p≤0.001;71.02±49.69 μiu/ml vs 47.67±40.03 μiu/ml P≤0.001 ;3.02±2.94 vs 1.8±0.95, p≤0.001),but the mean FBS and 2nd hour blood glucose during OGTT were not statistically different between two groups(89.56 ± 10.54 vs 89.93± 6.94; p=0.7 58 and 114.46±30.8 vs 108.85±32.48; p=1.699, respectively). The cutoff point of oxytocin for PCOS was 125ng/l ,with 70% sensitivity and 85.2% specificity and area under the ROC curve (AUC): 0.812± 0.033 (PConclusion: Oxytocin hormone is lower in PCOS group without relationship to their insulin resistance.

کلیدواژه ها:

Homeostatic model assessment of insulin resistance (HOMA-IR) ، Insulin Resistance (IR) ، Oral glucose tolerance test (OGTT) ، Polycystic ovary syndrome (PCOS) ، Oxytocin