The association between pancreatic function and genetic markers of obesity in breast cancer

Studies show that there is an association between obesity risk factors and cancer progression. The aim of this study was to investigate the association between pancreatic function and genetic markers of obesity in breast cancer. Methods: In this review study pancreatic function and genetic markers of obesity have been investigated. Moreover, the role of obesity genes in the pancreas function were discussed. Also theassociation between these genes to breast cancer were investigated. Results: Genetic factors are substantial determinants of overweight. Some of these genes that involve in obesity are FTO, MNX1 and leptin that plays an important roles in the control of food intake, energy expenditure, metabolism, and body weight. These factors also have a key role in the regulation of glucose homeostasis, even though acts central and peripheral mechanisms to modulate glucose metabolism, the pancreatic β-cell of the endocrine pancreas is a critical target of these genes actions. There is a link between the fat mass and obesity associated genes and a higher incidence of breast cancer. In this paper, an association was shown between genetic marker of obesity and breast cancer.Conclusion: Based on the findings, genetic marker of obesity have a significant role in pancreatic function and progression of breast cancer. Therefore, can be considered as the genes that roles in pancreatic development an attractive target for gene therapy of breast cancer.

کلیدواژه ها:

breast cancer ، obesity ، genetic markers ، pancreases