Anti-angiogenesis Therapy: New perspective in Breast Cancer treatment

The formation of new blood vessels from pre-existing vasculature(Angiogenesis) is one of the most important processes in tumor growth,invasion and metastasis. Tumors need their own blood supply and they can usethe nearby blood vessels only at first growth stage. So, prevention ofangiogenesis process is one of the targeted therapeutic methods, which reducesthe formation of new blood vessels. Recent study has been demonstrates the keyrole of angiogenesis process in growth of breast tumor cells and breast cancermetastasis. Angiogenesis is a tightly regulated multistep process and manyenzymes, growth factors, ECM proteins and their signal transduction pathwaysinvolved in this complex process. VEGFs are a group of important inducingfactor in tumor angiogenesis and a new field of anti-angiogenesis therapynamed, VEGF-targeted therapy is represented among breast cancer researchersin recent years. Recognition of the VEGF pathway as a key regulator ofangiogenesis has lead to development of several VEGF-targeted agents. Severalanti-angiogenesis therapeutic drugs are approved and combination of them withother therapeutic methods increased breast cancer patient quality life. However,wide study in biological tumor angiogenesis mechanism, side effect and drugresistance minimizing is of great significance for increasing the efficiency ofmethod. It is hoped that in the near future, anti-angiogenesis therapeuticmethods act as one of the most effective tools against breast cancer. Keywords:Breast cancer, Angiogenesis, VEGFs, anti-angiogenesis therapy, VEGFtargetedtherapy