Red meat consumption and risk of colorectal cancer: a systematic review

Colorectal cancer (CRC)has been most prevalent in developed countries. Development of CRC is closely associated with lifestyle, and diet may modulate risk. Red meat and dairy products have beenimplicated in colonic cancers. Several supporting mechanisms have been offered for the carcinogenic effects of red meat. This review examined the association between red meat consumption and risk of(CRC). Current data were obtained from electronic databases (PubMed and Google Scholar sites; until October 2017). References listed of included studies were searched to identify any potential study thatwas not captured in our electronic search. Articles were selected based on relevance to the subject. our search yielded 25articles.From the 25 articles, we identified 14 studies that evaluated the associationbetween red meat consumption and risk of (CRC). one of the studies showed A higher intake of Processed and red meat was significantly associated with a higher risk of colon cancer. Diabetes maypromote the development of CRC, and studies showed red and processed meats have to be associated with increased risk of diabetes. Meat processing produces PAHs and another carcinogenic N-nitrosocompound. In the digestive tract, heme iron from red meat mediates the formation of NOx. In (CRC) patients, consumption of heme-rich red meat increases the eventuality of flare relapse. In one studyhigh intake of beef was associated with decreased risk of colon cancer, whereas it was associated with increased risk of rectal cancer in men. However, it is not yet fully understood how red or processedmeat can increase the risk of (CRC). Higher intake of processed and red meat promotes the risk of (CRC) especially in men . higher intake of total meat associated with a higher risk of colon cancer. Avoidance of excessive consumption of total meat might be protective against developing (CRC). The growing burden of colorectal cancer can be curbed by reducing total meat consumption as well asfocusing on increasing dietary fiber intake as well as physical activity and increase participation in screening programs.

کلیدواژه ها:

Colorectal Cancer ، Lifestyle and Cancer ، Nutrition and Cancer ، Multidisciplinary Cancer Research ، Cancer Treatment and Management