An In-Silico Survey On The Structure And Function Of The Corresponding Antigens Of The Esophageal Malignancies InOrder To Immunotoxin Development

Esophageal cancer that refers to malignancies of the epithelium of the esophagus tissue, is sixthleading cause of death among cancers. This type of cancer is one of the most prevalent cancers inIran. So that, among 35,000 deaths of cancer in Iran, about 5800 cases of them is due to this type ofcancer. Considering, several methods with various efficacy have been developed in the world forprognosis, diagnosis and treatment of this disease. Among therapeutic approaches, immunotoxindevelopment with limited side effects is a desirable way. However, this strategy is demands tocharacterization of the cell surface specific antigens of esophageal cancer. Bearing in mind, acomprehensive profile of cell surface specific antigens of the esophageal cancer were gathered inthis study. Subsequently, the structural and functional characterizations of the antigens wereperformed, based on in-silico investigation. The results of this study led to the detection of sixspecific antigens for esophageal cancer with different structural, functional and expressioncharacteristics at the level of transcription and translation, including ADORA3, CLCA2, DSC3, LY6D,HER2, and MUC21. However, among them the MUC21with the highest level of the expressionconsidered as suitable biomarker for diagnosis as well as immunotoxin development. Accordingly,our investigation led to detection the corresponding ligands of the MUC21 as suitable context forimmunotoxin designing which are considered in our group for more analysis.