سیویلیکا را در شبکه های اجتماعی دنبال نمایید.

Evaluation of changes in expression of muc19 and muc21 genes in colorectal cancer tissues

سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 64

فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_JHGG-5-2_003

تاریخ نمایه سازی: 31 مرداد 1403

چکیده مقاله Evaluation of changes in expression of muc19 and muc21 genes in colorectal cancer tissues

Colorectal cancer is the third most common cause of cancer deaths in the world. Mucins are large glycoproteins that are expresses by epithelial cells in tubular organs. They recreate important functions in the regeneration and differentiation of epithelium, cell adhesion, immune response, and cellular signaling. In this study, mucin-19 and 21 gene expression were investigated in cancerous tumor samples, and tumor margins in patients with colorectal cancer. The purpose of working on these genes is their potential biomarker for the diagnosis of colorectal cancer. After extraction of RNA from 30 pairs of tumor and peripheral tumors of the colorectal tumor, cDNA was synthesized using a thermosetting kit, and RT-PCR was used to find the optimum temperature and specificity of primers. Then, real-time qPCR was performed to examine the difference between the gene expression of mucin on the tumor and tumor margins. This study showed an increase in the expression of mucin 19 in colorectal cancer tissue samples with tumor margins. Conclusion: The upregulation levels of mucin 19 gene can correlate with colorectal cancer progression. Therefore, Mucin 19 may be used as a biomarker for detecting colorectal cancer development.

کلیدواژه های Evaluation of changes in expression of muc19 and muc21 genes in colorectal cancer tissues:

نویسندگان مقاله Evaluation of changes in expression of muc19 and muc21 genes in colorectal cancer tissues

Yasamin Takhsha

Tehran Medical Sciences, Islamic Azad University

Maliheh Entezari

Tehran Medical Sciences, Islamic Azad University

Hossein Fahimi

Tehran Medical Sciences, Islamic Azad University

Hossein Dehghani

Tehran Medical Sciences, Islamic Azad University

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
Uncategorized References[۱] H. S. Gandomani, M. Aghajani, A. Mohammadian-Hafshejani, A. ...
F. A. Haggar and R. P. Boushey, "Colorectal cancer epidemiology: ...
A. P. Singh et al., "Aberrant expression of transmembrane mucins, ...
A. K. Bhargava et al., "Serum levels of cancer‐associated antigen ...
R. Bansil and B. S. Turner, "Mucin structure, aggregation, physiological ...
G. J. Strous and J. Dekker, "Mucin-type glycoproteins," Critical reviews ...
Y. Chen et al., "Genome-wide search and identification of a ...
T. Lang, G. C. Hansson, and T. Samuelsson, "Gel-forming mucins ...
Y.-F. Zhou, E. T. Eng, J. Zhu, C. Lu, T. ...
S. Duraisamy, S. Ramasamy, S. Kharbanda, and D. Kufe, "Distinct ...
P. A. Sylvester et al., "Differential expression of the chromosome ...
Y. S. Kim, J. Gum, and I. Brockhausen, "Mucin glycoproteins ...
M. A. Hollingsworth and B. J. Swanson, "Mucins in cancer: ...
A. Abulí et al., "Case-control study for colorectal cancer genetic ...
V. Kumar et al., "Genome-wide association study signal at the ...
J. E. Kerschner, P. Khampang, C. B. Erbe, A. Kolker, ...
M. Xu and X. Wang, "Critical roles of mucin-۱ in ...
R. J. King, F. Yu, and P. K. Singh, "Genomic ...
V. Vymetalkova et al., "Polymorphisms in microRNA binding sites of ...
Y. Itoh et al., "Identification and expression of human epiglycanin/MUC۲۱: ...
K. Okada, M. Kamata-Sakurai, Y. Itoh, K. Denda-Nagai, T. Ogawa, ...
نمایش کامل مراجع