Anti-Staphylococcus aureus Augmentation of Propolis by Incorporating in PVA Nanofibrous mat

In this study the possibility of using the propolis in a more expedient way, by incorporating the active compound in the nanofibrous mat was investigated. Polyvinyl alcohol (PVA) as a biodegradable and electrospinable material along with good biocompatibility character was chosen as the substrate. 40% w/w of hydroalcoholic extract of propolis (HEP) in PVA solution was electrospinned. Scanning electron microscopy (SEM) analysis showed that nanofibrous with 158.9 nm diameter have been produced. Fourier transform infrared spectroscopy (FTIR) confirmed the existence of active compounds inside the nanofibrous mats. Agar diffusion test method result showed 19mm inhibition zone against S.areus for nanofibrous mats containing HEP which was as good as the antibacterial effect of strong antibiotic, vancomycin standards discs. It was also found that using nanofibrous mat had positive effect on antibacterial activity of the produced mat compared to microfibrous mat and film.

کلیدواژه ها:

nanofibrous mat ، Propolis ، antibacterial wound dressing ، polyvinyl alcohol