Background:
Ovarian cancer (OC) is one of the most commonmalignancies and the eighth cause of death in women worldwide,and several genetic and environmental factors contribute to the development of this cancer, but its underlying mechanismis still unclear. The absence of specific symptoms in the earlystages has led to the
diagnosis of the disease in advanced stages,which causes the poor survival of these patients. Chemotherapyand radiotherapy are the most common
treatment methods forOC, which do not have satisfactory Results: In recent years,studies have shown that
biomarkers show multiple biologicalfunctions in different stages of OC development. On the otherhand, exosomes are a subset of extracellular vesicles that havea diameter of about ۳۰ to ۱۰۰ nm and are secreted by differenttypes of cells in different body fluids.
Exosomes contain varioustypes of genes related to OC, which can be potential biomarkersfor
diagnosis and
prognosis and even
treatment of OC.Materials and Methods: In this review article, ۴۷ valid articlesfrom PubMed and Google Scholar databases were used and thebest articles were selected. Search keywords include ovariancancer, exosomes, biomarkers,
diagnosis and treatment.Results: Late diagnosis, recurrence after surgery and resistanceto chemotherapy are the main reasons for the high mortality ofOC. The number of exosomes in plasma and serum is muchhigher in cancer than in healthy subjects, which is a promisingdiagnostic biomarker for OC. In fact, exosomes are valuableas screening
biomarkers for the prognosis,
diagnosis and treatmentof OC.Conclusion: OC is the deadliest cancer in women. However,efforts are underway to improve clinical outcome. Identificationof molecular signatures for targeted therapy of OC is becomingincreasingly important. From a therapeutic point ofview, the discovery of
biomarkers plays an important role inpredicting the outcome of chemotherapy, which is essential tohelp physicians.Undoubtedly, exosomes have a high therapeutic potential in theprognosis and
treatment of OC. However, the translation of thisidea to the clinic has not happened. Therefore, it is importantto understand how exosomes are used in OC to regulate tumorprogression.