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اُستادیار ؛ عضو هیات علمی دانشگاه آزاد اسلامی واحد علوم و تحقیقات تهران
425 یادداشت منتشر شدهThe Constituent Elements of The Synthesis of Nanoparticles in Biological Nano Robots (Nano Bio Robots), One of The Latest Methods in the Field of Nanoelectronics Technology

Note: DNA Origami is one of the newest techniques of using DNA as the building blocks for the synthesis of nanoparticles in biological nano robots (Nano bio Robots) . This is one of the latest methods in the field of nanoelectronics technology, which has its own limitations and opportunities. "Origami" is a Japanese word that means folding a simple sheet into a desired shape with a specific dimension.
Although DNA is the natural choice for making the active structures of DNA origami nano robots . It is not for nanorobotics applications, but due to the lack of structural and catalytic diversity, molecular walkers on origami and switches are also possible. DNA origami nanorobots display computational capacities and a pre-programmed task inside a living organism. In the structure of the DNA nanorobot they created, there is an open DNA tube that consists of a The side has a hinge and can be closed. The drug-loaded DNA tube is bound by a DNA aptamer and configured to identify and search for disease-related proteins. When DNA origami nanorobots hit infected cells, the aptamers dissociate and release the drug.

DNA origami takes a completely different approach from a multi-strand design. Usually, single-stranded circular genomic DNA of nanobots (Nano bio Robot) is used as a scaffold, and hundreds of short auxiliary strands called staples are used to assemble the longer scaffold into a specific structure. In the folding process, the scaffold DNA It acts as a guide or a seed, which increases the folding efficiency and resistance to the stoichiometry of the filaments in the Nano bio Robot.
Conclusion :
In general, DNA Origami is one of the newest techniques of using DNA as the constituent elements of the synthesis of nanoparticles in biological nano robots (Nano bio Robots) . This is one of the latest methods in the field of nanoelectronics technology, which has its own limitations and opportunities. "Origami" is a Japanese word that means folding a simple sheet into a desired shape with a specific dimension.