HN-01210150_Celiac Disease and Its Effect on The Incidence of Arthritis Rheumatoid

Introduction: Autoimmune diseases such as gluten-sensitive enteropathy (celiac) trigger the immune response by identifying native antigens as foreign agents and producing antibodies. Gluten (a protein found in wheat, barley, oats, and rye) triggers immune system to produce inflammatory cytokines in the gastrointestinal tract. It causes inflammation and destroys epithelial cells especially villi, so disrupts absorption, causes symptoms such as diarrhea, pain, and abdominal cramps.Methods: We searched documents from PubMed-Medline, Web of Science, and Cochrane Library.Results: In studies of patients suffering from both conditions simultaneously, gluten-free diet was recommended, and patients initially felt better in the gastrointestinal tract then in their joints. Inflammation and dryness in their hands and knees significantly decreased.Conclusion: We indicated the important role the gut plays in the pathogenesis of autoimmune disorders including arthritis rheumatoid. The intestinal permeability exposed the patient to exogenous antigens which could have been the initial trigger of an autoimmune response in the joints in a genetically susceptible patient. However, this clinical case is very controversial among researchers.

کلیدواژه ها:

Arthritis Rheumatoid ، Autoimmune ، Celiac ، Gluten