HN-01160103_The Relationship between Inflammation and Malnutrition in Hospitalized Patients

Introduction: Malnutrition has remained one of the important and common issues in hospitals. Malnutrition can increase side effects and mortality among hospitalized patients. Inflammation is a supportive response of the body against infection, acute diseases, toxic traumas, chronic disorders, and physical stress. Inflammation can affect body metabolism, composition and nutritional status. The aim of this research was to investigate the relationship between inflammatory factors and malnutrition among hospitalized patients. Method: This cross-sectional study assessed nutritional status of hospitalized patients in different departments using Subjective Global Assessment (SGA), Calf circumference (CC), Mid-arm circumference (MAC), Body Mass Index (BMI), and full Nutritional Assessment (FNA) tools. The inflammation condition of the patients was also evaluated by serum hsCRP level. Results: A total of 278 patients (135 women, 143 men) with a mean age of 54.4±5.27 and mean BMI of 21.6±3.3 were studied. Depending on the applied tool, the prevalence of malnutrition varied from 29% to 57.7%. The mean level of hsCRP serum in malnourished patients was higher than well-nourished patients. Mean levels of hsCRP serum in SGA, FNA, BMI, MAC, and CC methods, among well-nourished and malnourished patients were (25.36±16.21 mg/l vs. 17.94±18.2 mg/l ), (26.66±17.22 mg/l vs. 18.09±17.6 mg/l ), (20.26±16.9 mg/l vs.19.25±16.67 mg/l ), (26.6±17.33 mg/l vs. 23.97±19.65 mg/l), (24.65±18.99 mg/l vs. 22.74±18.6 mg/l) respectively. These differences were significant for MAC, FNA and SGA. Conclusion: Regarding the high prevalence of malnutrition among hospitalized patients and considering the impact of inflammation on the nutrition status, the inflammatory activities have to be evaluated promptly. Inflammation-induced malnutrition does not only necessitate nutritional intervention but also requires multi-aspect inflammation control treatments.

کلیدواژه ها:

malnutrition ، inflammation ، Subjective Global Assessment ، and full Nutritional Assessment ، Body Mass Index