Voluntary exercise modulates learning & memory and synaptic plasticity impairments in sleep deprived female rats

Background and Aim : Previous studies have indicated that forced exercise plays a preventive role in synaptic plasticity deficits in the hippocampus and behavioral impairments in sleep-deprived male and female rats. The objective of the present study was to evaluate the effects of voluntary exercise on early long-term potentiation (E-LTP) at the Cornu Ammonis (CA1) area of the hippocampus and behavioral functions by barnez maze and novel location tests in sleep-deprived female rats.Methods : Intact female Wistar rats were used in the present study. The exercise protocol was four weeks wheel running and the multiple platform method was applied to induce 72 h Sleep deprivation (SD). We examine the effect of exercise and/or SD on synaptic plasticity using in vivo extracellular recording in the CA1 area of the hippocampus. Spatial learning and memory examined by barnez maze and recognition memory assessed by novel location test.Results : Field potential recording indicated that the induction and maintenance phase of E-LTP impaired in the sleep deprived animals compared to the other groups. After 72 h SD, E-LTP impairments were prevented by 4 weeks of voluntary exercise but But do not go back to control values.SD impairs learning and memory and exercise could improve these deficitsConclusion : In conclusion, the synaptic plasticity deficit in sleep-deprived female rats was improved by voluntary exercise. Further studies are suggested to evaluate the possible underlying mechanisms.

کلیدواژه ها:

Sleep deprivation (SD) ، Voluntary exercise ، synaptic plasticity ، LTP ، Learning and memory