Effects of Intrahippocampal Injection of Montelukast on Rotarod Performance in Wistar Male Rats

Background and Aim : Studies have shown that Montelukast may affect on movement disorder. The aim of this study was to investigate the effects of injection of Montelukast into hippocampus on motor coordination in male rats.Methods : In this laboratory-experimental study,15 male rats were obtained from Neuroscience Research Center- Shahid Beheshti University of Medical Sciences, Tehran, Iran. Animals were divided to control, sham and Montelukast (1μL) receiving groups. Motor coordination was evaluated using Rotarod. The data were statistically analyzed between groups using ANOVA.Results : Motor performance did not significantly alter in Montelukast receiving animals compared with control group.Conclusion : Despite certain reports, the findings of this study showed that Montelukast had not significant positive or negative impact on the motor coordination in the male rats.

کلیدواژه ها:

Montelukast ، Memory ، Motor coordination ، Male rat