Prediction of seizure incidence probability in PTZ model of kindling through spatial learning ability in male and female rats

Methods : Herein we investigated whether seizure susceptibility in pentylenetetrazol (PTZ) model of kindling is predictable based on the learning ability in the Morris water maze (MWM) task in male and female rats. Allocentric learning was tested using MWM in present of light while egocentric learning was evaluated by MWM in dark room.Results : The results indicated no significant differences in allocentric learning abilities between male and female rats. However, male rats were able to memorize the location of the platform more effectively compared to females in egocentric test. In addition, a statistically significant negative correlation between learning abilities (working memory) and seizure susceptibility in male rats was found while this correlation was positive in female rats. On the other hand, although there was no significant correlation between retrieval (reference memory) of spatial memories and seizure parameters in male rats, female rats showed a significant negative correlation.Conclusion : These findings may provide some evidences for prediction of seizure susceptibility according to learning ability and memory retention.

کلیدواژه ها:

Allocentric learning ، Egocentric learning ، Epilepsy ، Retrieval of memory ، Rat ، Spatial memory