A Comprehensive Study of Possible Crosstalk between Angiogenic and Metabolic Signaling Pathways in Cancer

Sea buckthorn or Elaeagnus rhamnoides is thorny tree with the height of 1 to 3m growing in Europe, western and central Asia to the west of china and northwest of Himalaya and in Iran it is found in Alborz mountain to Azerbayijan and Taleghan and Karaj valley. It has long and narrow leaves, sharped with the length of 5-6and one cm width. Its fruit is sphere, yellow and orange with sour taste. Different parts of plant particularly its fruits have phenolic compounds, vitamins (especially vitamin C), unsaturated fatty acids, and phytosterols such as beta-sitosterol beign investigated by some researchers. These fruits have useful antioxidant, anti-inflammatory and anticancer effects. It has also anti-proliferation properties and can induce apoptosis and stimulate the immune system; sea buckthorn oil counteracts many side effects of chemotherapy by restoring kidney and liver function, increasing appetite, and keeping general good health. Although the anticancer activity of sea buckthorn has been confirmed by many in vitro and in vivo animal studies, measurements should be taken for the development of well-controlled clinical experiments to determine the therapy and preventive does in this area. The present study discusses briefly about whether sea buckthorn is used as an anti-inflammatory and anticancer drug or not.