The effects of chronic administrations of Niacin on the anthropometric and ovarian morphological changes PCO rats

Background: Polycystic ovary syndrome (PCOS) considered as a prevalent endocrine syndrome in women of reproductive age. Patients with PCOS reveal body and ovary weight alternations and substantial histological changes in the ovaries. Based on these evidences that Niacin can modulate insulin sensitivity through the adiponectin secretion, this study was conducted to evaluate the role of Niacin on PCOS complications such as body and ovary weight gain, ovarian morphological parameters in PCOS rats.Objective: Present study was conducted to determine the effects of Niacin on different complications of PCOS.Materials and Methods: Female Wistar rats with normal estrus cycle (n = 28) were allocated into 4 groups of seven animals. PCOS was induced by the intramuscular injection of 4 mg estradiol valerate. The control group was treated with saline while the PCOS groups were orally administered with Niacin (25 or 50 mg/kg) and clomiphene citrate (25 mg/kg) respectively. Four weeks after the treatments anthropometric parameters were measured and ovarian morphological changes were evaluate using Hematoxtlin-Eosin staining method.Results: The result of study revealed that Niacin at different doses reduced body weight gain and improve ovary weightin compared to control group (p<0.05). although the number of healthy follicles did not change in different groups, the cystic follicles were increased significantly in the PCOS and Niacin therapy could improve the increased the follicles in treated rats (p<0.05). Diminished corpora lutea and increase in thickness of theca interna in PCOS rats were significantly improved in rats treated with Niacin in compared to control rats (p<0.01).Conclusion: Consumption of Niacin can improve body and ovary weight gain. Also, Niacin induces beneficial impacts on ovarian morphological changes that induce in PCOS.

کلیدواژه ها:

Polycystic ovary syndrome ، Rat ، Nicacin ، Ovary morphology