Taurine improves the function of mice ovary grafts through reducing oxidative stress

Background: Ovarian tissue transplantation is an experimental procedure for preserving fertility in cancerous patients facing reproductive function failures. ischemia/ reperfusion (IR) injury is one of the major limitations of ovary transplantation, which leads to the excessive production of reactive oxygen species (ROS). Taurine as a strong antioxidant is a suitable candidate for preventing I/R injury.Objective: We aimed to investigate the effect of taurine on ovary function following autotransplantation.Materials and Methods: The Naval Medical Research Institute (NMRI) mice (4-5 wks old) were divided into three groups: control; autograft +saline, and autograft +Taurine (i.p injections 200 mg/kg/day). Treatment was carried out one day before till 7 days after transplantation. Seven days after ovary autografting, serum concentrations of malondialdehyde (MDA) and the total antioxidant capacity were estimated. 28 days post transplantation, serum concentrations of progesterone (P4) and estradiol (E2) were also evaluated. The results were analyzed using one-way ANOVA and Tukey’s test and the means were considered significantly different at p<0.05.Results: A significant decrease in the total antioxidant capacity, concentration of progesterone and estradiol was found in the autografted group compared to the control group (p<0.001). The Concentration of MDA significantly increased in the autografted group compared to the control group (p<0.001). The mentioned parameters were ameliorated to the control level in the autografted + Taurine group.Conclusion: Our results indicated that the administration of taurine reduces oxidative stress, increases the total antioxidant capacity and restores the hormone levels in the grafted ovaries which can improve the function of the grafted ovary.

کلیدواژه ها:

Autotransplantation ، Ovary function ، Taurine ، Mice