Does Time lapse monitoring (TLM) improve assisted reproductive outcomes

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 386

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شناسه ملی سند علمی:

RMED08_013

تاریخ نمایه سازی: 21 مرداد 1398

چکیده مقاله:

High implantation rates following ART cycles are achieved via the transfer of embryos with the highest developmental competence. Multiple pregnancies as a result of the transfer of several embryos per cycle accompany with various complication. Therefore, single-embryo transfer (SET) is the preferred practice in ART program to avoid various complications of multiple pregnancies. For improving the pregnancy rates for SET, the embryologists need reliable biomarkers to aid their selection of embryos with the highest developmental potential. Embryo conventional morphological assessment limited to discrete snapshots once a day. Also, it exposes the embryos to suboptimal conditions regarding to pH, light and temperature outside the incubators. Continuous observation of embryos via time-lapse monitoring (TLM) provides detailed information on embryo morphokinetics with stable culture condition. Moreover, TLM may introduce new dynamic parameters of embryo developmental potential as well as a versatile embryo assessment and provides new information regarding human embryo competence. Recently, several algorithms have been developed associated with the morphokinetics of early embryo development to formation of blastocyst, implantation potential, chromosomal content, pregnancy and live birth rates. We found that oocyte quality such as morphology, morphometry, presence of the meiotic spindle (MS), zona pellucida (ZP) birefringence and maturity might affect on the generated embryo morphokinetics. But, pronuclear pattern of fertilized oocytes was not related to embryo morphokinetics. However, there is not yet a universally consensus about them and there are significant knowledge gaps that can give opportunities for further studies in this field.

نویسندگان

A Faramarzi

Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran- Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

MA Khalili

Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran