Genetic risk factors for tendency to suicide detected in a GWAS study

Suicide is a major public health problem, which kills almost one million individuals each year in world population. Psychological risk factors for suicidal behaviors are including, psychiatric and medical illness, impulsivity, aggression, alcohol and drug abuse specially stimulants, and low stress resilience. Genetic risk factors of suicide are not completely clarified. Present study aimed to detect genetic risk factors that increasing the vulnerability to committing suicide. DNA was extracted from blood samples of 100 saved suicide victims with at least one attempt to suicide in last 12 months and 150 healthy subjects. Genotyping for the subjects was performed using the Affymetrix Genome-Wide Human SNP Array 6.0 (Affymetrix, Santa Clara, CA) according to the manufacturer’s protocol. Several SNPs were detected with genome-wide significance. The significant association found in 77 SNPs involved in dopaminergic pathway and neurodevelopment of CNS. 56 of significantly related SNPs were found as risk factors of psychiatric disorders specially schizophrenia and obsessive compulsive disorder; other 21 SNPs were related to the mitochondrial complexes, transcription factors and growth factor genes. The study was showed genetic bases of suicidal thoughts and could be used for providing genetic prognostic markers for prediction of suicide risk especially in subjects with psychosis. Also importance of mitochondrial complexes and growth factors in neuorobilogical functions and decision making processes in brain has been showed.

کلیدواژه ها:

Suicide tendency ، SNP array ، mitochondrial complexes ، growth factors