Protective Effects of the Hydroalcoholic Extract of Fumaria Parviflora on Testicular Injury Induced By Torsion/Detorsion In Adult Rats
محل انتشار: چهارمین کنگره بین المللی تولیدمثل
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 500
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شناسه ملی سند علمی:
ISERB04_194
تاریخ نمایه سازی: 16 تیر 1397
چکیده مقاله:
This study was designed to determine the effects of daily oral administration (250 mg/kg) of the hydroalcoholic extract of Fumaria parviflora (FP) for 14 days on the sperm parameters, oxidative stress parameters, serum testosterone levels, expression of Bax and Bcl-2 genes, and apoptosis index of germ cells after testicular torsiondetorsion(ischemia-reperfusion, IR) injury model in rats. Twenty-eight adult Wistar rats were divided randomly into four groups of 7 each:sham operation, torsion-detorsion (TD), TD plus the hydroalcoholic extract FP (TDFP), only FP without TD application (FP). Testicular torsion was created by rotating the left testis 720° in a counterclockwise direction, then, after 4 hours, detorsion was performed. The Johnson’s score, mean seminiferous tubule diameter (MSTD) and height (thickness) of seminiferous tubule epithelium (HST) were significantly increased in TDFP and FP groups as compared with TD group. The gene expression of Bcl-2, level of serum testosterone hormone, and antioxidantparameters—GPx and SOD—were significantly higher in TDFP and FP groups than TD group. The index of apoptosis, the gene expression of Bax, and the level of MDA were significantly higher in TD group than TDFP and FP groups. Therefore, Fumaria parviflora could decrease oxidative stress induced by testicular torsiondetorsion.
کلیدواژه ها:
نویسندگان
Hamed Shoorei
Department of Anatomical Sciences, Faculty of Medicine,Tabriz University of Medical Sciences
Majid Shokoohi
Department of Anatomical Sciences, Faculty of Medicine,Tabriz University of Medical Sciences
Amir Afshin Khaki
Department of Anatomical Sciences, Faculty of Medicine,Tabriz University of Medical Sciences
Maryam Moghimian
Department of Basic Sciences, Faculty of Medicine,Gonabad University of Medical Sciences