The Effect of Royal Jelly on Some Reproductive Parameters in Female Rats

Objectives: Royal jelly (RJ) is a complementary medicine widely used by traditional healers for the treatment of infertility. The aim of present study was to evaluate the effect of RJ on some reproductive parameters in adult female rats. Methods: Twenty-eight adult female rats (180-200 gr) were divided into four groups (n=7 /group). Control group received 0.5 ml distilled water intraperitoneally (i.p), experimental groups received: 100, 200 and 400 mg/kg/body weight doses of RJ daily for 14 days respectively. Animals were sacrificed and ovaries were dissected for histopathologic examination; the serum levels of ovarian hormones were evaluated. The ratio of the ovarian and uterine weight to body weight was calculated. One-way ANOVA was used for data analysis.Results: 7KH ERG ZHLJKW ZDV VLJQL FDQWO increased (p=0.004) in 100, 200 and 400 mg/kg RJ treated animals. The serum levels of progesterone (p=0.013) and estradiol (p=0.004) were increased in experimental groups significantly. In addition, histopathological data of ovaries showed a significant increase in the number of mature follicles and the number of corpora lutea (p=0.007).Conclusion: The overall results of the present study provide evidence on the ovarian folliculogenesis effect of RJ in female rat.

کلیدواژه ها:

Royal jelly ، Fertility ، Ovary ، Uterus ، Rat