Prognostic value of preoperative inflammatory markers in patients with breast cancer

Introduction & Aim: Breast cancer is the most common cancer among females, and the incidence has increased greatly in recent years. Cancer-associated inflammation is a key determinant of disease progression and survival in most cancers. The aim of our study was to assess the predictive value of preoperative inflammatory markers, such as the neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio, red cell distribution width (RDW), and mean platelet volume, for survival in breast cancer patients.Methods: In total, 60 breast cancer patients operated on between January 2009 and January 2016 were included in this observational study. The association between preoperative inflam matory markers and survival outcomes was analyzed. Results: Patients with high NLR (2.57) or high RDW (13.45%) showed a significantly lower overallsurvival rate than those with lower NLR (2.57) or lower RDW (13.45%). NLR and RDW, along with node stage and molecular subtypes, were independent prognostic factors.Conclusion: Preoperative NLR and RDW is a convenient, easily measured prognostic indicator in patients with breast cancer, especially those with the triple-negative subtype. These results suggest that cancerassociated inflammation in triple-negative breast cancer may play a greater role in promoting breast cancer progression than the other subtypes. However, further validation studies are required

کلیدواژه ها:

neutrophil-to-lymphocyte ratio ، NLR ، red cell distribution width ، RDW ، overall survival