Lithium carbonate inducing disorders in three parameters of rat sperm
محل انتشار: سومین کنگره بینالمللی تولیدمثل
سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 380
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شناسه ملی سند علمی:
ISERB03_276
تاریخ نمایه سازی: 11 خرداد 1397
چکیده مقاله:
Background: Lithium has a significant impact in reducing the symptoms of bipolar mania, but in long periods of use with therapeutic doses can cause several disorders in various organs including the reproductive system. In this study, the effect of lithium on the sperm concentration and motility and forms of abnormal cells have been examined.Methods: Male Wistar rats under the 48-day treatment with lithium carbonate at doses of 10, 20, and 30 mg/kg bw/day were kept in standard conditions. At the end of this period, sperm cells isolated from the cauda epididymis were counted, motility was estimated, and stained with smear papanicolaou stain.Result: In lithium-treated groups, the rate of spermatogenesis and sperm quality was reduced and observed in a dose-dependent manner.Conclusion: Lithium alters intracellular signaling pathways such as inositol phosphate metabolic cycle and cyclic adenosine mono phosphate (cAMP) system and adenosine triphosphate (ATP) synthesis. It also interferes in the division of sex cells to produce mature sperm and showed changes in the sperm cell membrane, function, and structure.
کلیدواژه ها:
نویسندگان
Shima Toghyani
Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran
Gholam Reza Dashti
Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Nasim Hayati Roudbari
Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran
Shaila Rouzbehani
Department of Biology, Islamic Azad University, Falavarjan, Isfahan, Iran.