The protective effects of pomegranate seed oil on sperm parameters and spermatogenesis quality

Background: Fruits are rich source of antioxidant with significant potentials in neutralizing adverse impacts of lead on sperm parameters. The present study aimed to determine the effects of pomegranate seed oil on sperm parameters and spermatogenesis quality in adult rats exposed to lead.Methods: This was an experimental study conducted on male wistar rats (n=45) weighing 180±20 g that randomly divided into 5 groups (n=9):distilled water gavage (control); intraperitoneal distilled water; pomegranate seed oil (PSO); lead; and lead plus PSO(LPSO).The animals received a 30-day treatment and then were sacrificed for the sperm parameters assessments. Sperm count, motility and morphology assessment, chromatins, epididymis and testis weights were performed. The collected data were analyzed by Kruskal-Wallis, Wilcoxon,Mann-WhitneyU-test,and Chi-square using SPSS (version13) software. Statistical significance was set as P< 0.05.Result: The results showed statistically significant differences on weight gain, epididymis weight, sperm inviability rate, and high sperm motility between the groups (P0.05).Conclusion: PSO has positive effects on weight gain, epididymis weight, and viable sperm percentage in rats and reducing the lead induced toxic effects on sperm viability. conclusion:PSO has positive effect on spermatogenesis and Sperm Parameters.

کلیدواژه ها:

Antioxidant ، Lead acetate ، Pomegranate seed oil ، Spermatogenesis