Impacts of conjugated linoleic acid on metabolic, hormonal status and sperm parameters in male mice model of obesity induced by different oils

Background: Preventing or treating obesity in male has a positive effect on fertility rates. Since conjugated linoleic acid (CLA) can reduce the obesity, the purpose of this study was to investigate the impacts of CLA on metabolic-hormonal status and sperm parameters in male mice model of obesity induced by different oils.Methods: In this cross-sectional study, 60 male NMRI mice were used. They were randomly divided into 6 groups delivering different sources of oil including: A (Fish oil), B (Olive oil), C (Hydrogenated sunflower oil), D (Flax oil), E (Dehydrogenated sunflower oil), and F (Control). After 14 weeks of being on a diet of different oils, 5 mice of each group continued their diet of different oils and 5 remaining mice of each group were treated with CLA for 4 more weeks. Following 18 weeks, blood samples were collected from the heart to determine the blood metabolites and hormones. Spermatozoa were obtained from the epididymis to assess sperm parameters.Result: The highest HDL level was observed in the dehydrogenated sunflower oil group. CLA treatment reduced HDL levels significantly in this group (P=0.0005). Olive oil increased triglyceride concentrations compared to the control group. CLA treatment decreased triglyceride in the olive oil group (P=0.03). Fish oil increased FSH significantly. CLA treatment reduced FSH levels significantly in the fish oil group (P=0.0001). Most abnormal sperm morphology was observed in hydrogenated sunflower oil and olive oil. CLA reduced abnormal morphology of sperm in hydrogenated sunflower (P= 0.03) and olive oils (P=0.05).Conclusion: CLA treatment could attenuate negative impacts of different oils specially sunflower and olive oils on sex hormones and sperm parameters.

کلیدواژه ها:

Conjugated linoleic acid ، Hormone ، Oil ، Spermatozoa ، Obesity