The effects of chemical drugs affecting on the eradication of Helicobacter pylori

Helicobacter pylori is cram-negative bacilli and is micro aerophilic of its elements are duodenal ulcer, gastroin testinal malignancies, acute gastritis and chronic gastritis. Anti-bacterial agents. That more than others have been used in eradication of helicobacter pylori Include: metronidazole, amoxicillin, bismuth, tetracycline, and clari-thromycin. Prevention by removing the colonization of a population may involve apparent losses. In treatment of helicobacter pylori, mono the ray has failed and its reason has likely been the inadequate delivery of antibiotics to the colonization area. The first line: when the resistance to clarithromycin is low, this regime is better. the rate of eradication by this regime is low and there is little therapeutic effect. the most important factor for this is the resistance of helicobacter pylori to antibiotics especially to clarithromycin in the last decade. The second line: quadruple drug regimen containing bismuth along with tetracycline metronidazole, drugs that suppress acid is the best choice. But the above diet therapy is not a good regimen because of the long duration of treatment, side effects, large number of tablets per day and that bismuth may not be found everywhere. The third line: three-drug regimens based on rifabutin, levofloxacin, tetracycline along with amoxicillin and a proton pump inhibitor or high-dose amoxicillin are proposed. Live saving treatment: After two treatment failure, Antibiogram text should be conducted and otherwise the best treatment is the second line. When the resistance to clarithromycin and fura-zulidon are simultaneous or when there is susceptiobility to bacteria, after the second failure, one can use regimes based on rifabutin, levofloxacin, furazolidon. Our suggestion is druge regime bused on ciprofloxacin, omeprazole and probiotic to lessen the side effects

کلیدواژه ها:

Helicobacter pylori ، treatment ، drug regimen ، eradication