Effect of tamoxifen-loaded solid lipid nanoparticles on serum parameters of adult overoctomized Wistar rats

Introduction: Tamoxifen (TAM) is administered for the treatment of hormone-responsive cancers. Recently, nanoparticles carriers for tamoxifen loading were suggested to reduce the side effects of the drug. An in vivo study was conducted to determine the effect of tamoxifen-loaded solid lipid nanoparticle on serum parameters of adult overoctomized female Wistar rats. Methods: In this study, thirty adult female rats were divided randomly into five groups. Group I served as healthy control animals. The other four groups were overoctomized and treated with olive oil, tamoxifen (TAM) dissolved in olive oil, tamoxifen-loaded solid lipid nanoparticle and solid lipid nanoparticle (SLN) respectively. The treatments were given orally for 21 days consecutive to the animals using gastric intubations. At the end of the study, the blood samples were obtained from the rats and were analyzed to determine serum parameters. Results: The serum analysis showed that the levels of uric acid, creatinine and triglyceride decreased non-significantly (p> 0.05) and also levels of cholesterol and LDL-cholesterol decreased significantly (p<0.05) in group that treated with TAM-loaded SLN compared to control group (untreated). Conclusion: The study suggests that TAM-loaded SLN as a new drug delivery system is suitable for menopause women and may decrease the risk of heart disease.

کلیدواژه ها:

Menopause ، Serum parameters ، Solid lipid nanoparticles ، Tamoxifen