Evaluation of mage-1 antigen in the serum of breast cancer patients and its correlation with prognostic factors

Breast cancer is the most common cancer among women in the world. Melanoma-associated antigen (MAGE) is one of the subfamilies of cancer testis antigens. The first member of the human MAGE-family was identified as a gene encoding the tumor-specific antigen. These genes are completely silent in natural tissues except for male germ cells and perhaps placenta. It is thought that this antigen is apromising candidate for the diagnosis of cancers.The aim of this study was to determine the level of MAGE-1 in serum samples of patients with breast cancer and examine its relationship with otherknown prognostic factors, including hormone receptor status ER/PR (estrogen/progesterone) and HER2.Totally 78 patients with breast cancer at Omid University-Hospital in Mashhad have includedthe study. Serum samples were taken, after obtaining informed consent level of MAGE-1 was measured in the collected sera by a commercial ELISA kit according to manufacturer s instructions.MAGE-1 was observed in 63 out of 78 patients (80%). There was as a significant relationship between MAGE-1 level and tumor staging (p=0.048): also, a statistically significant relationship was shown between MAGE-1 and estrogen receptor positivity (ER) (p=0.008).Serumic level of MAGE-1 showed a relationship with the stage of tumors also a correlation was between MAGE-1 and ER positivity. These findings make MAGE-1 a promising prognostic factor in breast cancer, though further studies with larger sample size still are recommended to confirm its prognostic role and possible clinical application

کلیدواژه ها:

Breast Cancer ، Cancer Prevention ، Cancer Risks ، Cancer Treatment and Management ، Targeted Cancer Therapy