Leu432val polymorphism of cytochrome p4501b1 gene as a biomarker in patients with oesophageal squamous cell carcinoma

Esophageal cancer has been reported as the eighth most common cancer universal and the seventh cause of cancer-related death in men. Recent studies have revealed that cytochrome P450, family 1,subfamily B, polypeptide 1, which plays a role in metabolizing xenobiotics, is associated with different cancers. Therefore in the present study, we investigated the impact of Leu432Val polymorphism ofcytochrome P4501B1 on esophagus squamous cell carcinoma (ESCC) patients. overall 317 subjects, with and without ESCC were recruited. DNA was extracted and genotyped via Real-time PCR-BasedTaq Man. Kaplan Meier curves were utilized to assess overall and progression-free survival. To evaluate the relationship between patients clinicopathological data, genotypic frequencies, disease prognosis, and patients survival, Pearson chi-square and t-test were used. Logistic regression was utilized to assess the association between the risk of ESCC and genotypes. With respect to the recessive genetic inheritance model, an association between the GG genotype and stage of ESCC were found. Also, statistically significant results were not found for this variation and risk of ESCC. Our findings illustrated the correlation of Leu432Val polymorphism of cytochrome P4501B1 as a potential biomarker for ESCC patients, supporting further studies in larger populations in different ethnic groups

کلیدواژه ها:

Gene and Cancer ، Cancer Risks ، Cancer Genetics ، Cancer Treatment and Management ، Drugs and Cancer