The prognostic value of a genetic variant in cdkn2a/b locus in cervical cancer

Cervical cancer (CC) is among the most common diagnosed cancer. Several genetic variants have been identified in the 9p21 region with the risk of developing several cancers. Thus, the aim of current study was to investigate the association of rs1333049 in chromosome 9P21 in patients with cervical cancer.DNA was extracted from 221 subjects with and without CC and genotyped by TaqMan real-time PCR. Logistic regression was utilized to assess the relationship between CC risk and genotypes.The significant prognostic variables in the univariate analysis were included in multivariate analyses.Our data showed patients with CC had a higher frequency of GG genotype for rs1333049 than individuals in the control group. Moreover, GG genotype was associated with the increased risk of developing cervical cancer in recessive genetic model (e.g., OR: 3.2, 95%CI:1.7-6.2, p<0.001) as well as other models. We demonstrated the association of a novel genetic variant in CDKN2B gene with cervical cancer, supporting further studies in a larger population and multi center setting to explore the value of emerging marker as a risk stratification marker in cervical cancer.

کلیدواژه ها:

Cervical Cancer ، Cervical Cancer ، Cancer Diagnosis ، Gene and Cancer ، Cancer Risks