The Role Of Curcumin In Cancer Treatment: The Call Of Nature

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 320

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NASTARANCANSER02_165

تاریخ نمایه سازی: 22 دی 1396

چکیده مقاله:

Cancer is one of the leading causes of morbidity and mortality worldwide, with nearly 14 millionnew cases and 8.2 million cancer related deaths in 2012. Available anti – cancer drugs have severeside effects and are also expensive. So, the more researches for identifying new pharmacologicalagents, without this disadvantages, are needed. Curcumin, a polyphenolic compound which derivedfrom Turmeric, is one of such agents. Turmeric is a rhizome from the herb Curcuma Longa. Itspowder has MM % Curcumin that has been shown to be pharmacologically safe compound with a verylow or no toxicity. We searched the PubMed and Google Scholar databases using the search terms:Curcumin, Cancer and Clinical Trial. 15 studies were identified and reviewed. The articles werepublished from 2002 up to 2016. Among studies, There was an emphasis on apoptotic, anti –proliferative and anti – angiogenic properties of Curcumin. It can suppress cell growth and tumorformation by inhibiting several cell signaling pathways such as transcription factors (NF-kB and AP-1), enzymes (COX-2, MMPs), cell cycle arrest (cyclin D1), proliferation (EGFR and Akt), survivalpathways (bcatenin and adhesion molecules), and TNF. Curcumin up-regulates caspase familyproteins and down-regulates anti-apoptotic genes (Bcl-2 and Bcl-XL). Pre – clinical studies in a in avariety of cancer cell lines including breast, cervical, colon, lung, gastric, hepatic, leukemia,melanoma, lymphoma, oral epithelial, ovarian, pancreatic, and prostate have demonstrated thatCurcumin has anti – cancer activity in vitro and in pre – clinical animal models. It s important thatcancerous cells arrested in mitosis due to Curcumin treatment, acquire double – strand DNAdamage. Curcumin also induce apoptosis in cells selectively. Thus using Curcumin as an anti –cancer drug is safe and without side effects. A study showed Curcumin induces cell apoptosis in Non– Small cell lung cancer by increasing the level of intracellular free calcium. NSCLC is responsiblefor nearly 85% of the total lung cancer cases that isn t sensitive to the majority of conventionalcytotoxic treat ments, such as chemotherapy and radiotherapy. In another studies, showed thatCurcumin can suppress the proliferation of both the androgen-dependent prostate cancer cell line,LNCaP, and the androgen-independent DU145 line. And also in a clinical trial on intravaginalapplication of curcumin based capsule or vaginal cream at bed time for 4 weeks has shownremarkable (∼80%) clearance of the virus. HPV is a small DNA tumor virus which has been shown tobe prevalent in about 90% of cervical cancers and M0% of vaginal cancers. Curcumin, A derivative ofturmeric, has great anti – cancer effects, demonstrated by various researches. Although Curcumin –based drugs in near future will play a significant role in healing cancer patients, using turmericpowder as a dietary supplement is an easy way toward cancer treatment and chemoprevention.

نویسندگان

Mohammad Ali Emrani

Faculty Of Medicine, Mashhad University Of Medical Sciences (MUMS), Mashhad, Iran