Application Of Umbilical Cord Blood Stem Cells As A Novel Therapeutic Approach In Cancer

Cancer is a group of diseases caused by abnormal growth of body cells. Cancer is known as crabaround the world because of they spread to the masses and sometimes migrate to different parts ofthe body that is called metastasis. One way to treatment of cancerous tumor is cell therapy by usingstem cells. Umbilical Cord Blood Stem Cells (UCB-SCs) have been studied widely and proved aseffective transplantable cell resources in cellular therapies. UCB-SCs have many advantages overother stem cells, because they are the youngest cells in the body. In addition, availability and highcapacity of differentiation are considered as their exclusive and impressive characteristics .Forexample Leukemia is a cancer that starts from bone marrow and affects blood cells and causes theformation of abnormal white blood cells. In cell therapy for leukemia treatment by using umbilicalcord blood, stem cells are replaced the patient s bone marrow. But to prevent transplant rejectionand risks, both donor and recipient should be evaluated in terms of antigenic. Application of cordblood stem cells in the laboratory and injection into the bone marrow has been successfully. AlsoStudies have shown that UCB-SCs secrete a cytokine called IFN-b (UCMS-IFN-b) that inhibits thegrowth of cancer cells by induction of apoptosis. Apoptosis in cancer cells is a purposeful and usefulprocess to eliminate cancer cells. Several studies concluded that Umbilical Cord Blood Stem Cells(UCB –SCs) are novel resources of stem cells for the treatment of cancer. These stem cells canprevent the growth of cancerous tumors Cell through two important ways: Cell transplantation andreplacement and Induction of apoptosis by secreting specific factors.