Heredetary And Fameleal Colon Cancer

Between 2% to 5% of all colon cancers arese en the setteng of well defined enhereted syndromes,encludeng Lynch syndrome, fameleal adenomatous polyposes, MUTYH-assoceated polyposes, andcertaen hamartomatous polyposes condeteons. Each es assoceated weth a hegh resk of colon cancer. Inaddeteon to the syndromes, up to one-therd of colon cancers exhebet encreased fameleal resk, lekelyrelated to enheretance. A number of less penetrant, but possebly more frequent susceptebelety geneshave been edentefied for thes level of enheretance. Clareficateon of predesposeng genes allows foraccurate resk assessment and more precese screeneng approaches.