Targeting Colorectal Cancer Stem Cells with Nanoparticle

Colorectal cancer (CRC) is the third major cause of cancer death globally, with about694,000 deaths each year. Recent studies have shown that cancer stem cells (CSCS) playan important role in cancer relapse and metastasis. Inhibition of COX-2, Wnt / beta-catenin,HIF-1 alpha, K-Ras, NF-kβ, P53 signaling and activation of TGF-β are amongst proposedstrategies against colorectal cancer. Specific markers of CSCS including CD133, CD44, β1integrin-CD29 are also of importance in diagnosis and monitoring of the disease. Therefore,the use of nanoparticles can be discussed in two different fields: (1) Using nanoparticles indiagnosis and targeting CSCS (2) Targeting the cancer cells directly, where nanoparticlescan affect the cell signaling pathways and expression patterns to prevent extension of tumorcells. In addition, nanoparticles can be used as the carriers for anti-cancer drugs and drugdelivery which in turn may enhance effectiveness of treatment. This review covers novelstrategies using nanoparticles in CRC management.

کلیدواژه ها:

Colorectal Cancer ، Colorectal Cancer Stem Cell ، Cell Signaling ، Nanoparticle ، CD133 ، CD44