Growth performance parameters in chicken experimental coccidiosis treated with Diclazuril and Clopidol: The need for assessing new anticoccidial resources

BACKGROUND: Coccidiosis is recognized as the parasiticdisease that has the greatest economic impact on poultry production.Modern poultry production is largely dependent uponanticoccidials. OBJECTIVES: The aim of the present study wasto determine and compare the efficacy of two chemical anticoccidials(Clopidol and Diclazuril) on oocyst shedding and theirprobable effects on growth performance and feed efficiency ofbroilers in experimental coccidiosis. METHODS: One hundredand twenty Ross 308 one day old broilers were randomly assignedinto 4 groups: CON+, infected with Eimeria mixed oocystsbut not medicated; CON-, not infected and not medicated;CLO, infected and medicated with Clopidol; DIC, infectedand medicated with Diclazuril. Chickens in all groups exceptnegative control were inoculated by mixed sporulated oocystsof pathogenic Eimeria at the end of the 3rd week of age. Oocystshedding was counted using a Mc Master counting chamber.Body weights, body weight gains, and feed conversion ratiowere determined on weekly basis. RESULTS: Obtained resultsshowed that Diclazuril was more effective in reducing oocystshedding than Clopidol. As expected, mean body weight inthe positive control group was lower than other groups. Butsurprisingly, no significant difference was found between Diclazurilor Clopidol treated birds and positive control group,at the end of the experiment. In comparison of weight gain indifferent treatment groups except for the 4 and 5th week, nosignificant difference was found in different groups. In the lastweek of the experiment, difference in weight gain betweengroups was not significant. According to feed conversion ratio(FCR) results, anticoccidial supplementation did not haveany significant effect on improving FCR. CONCLUSIONS: It isreported that some anticoccidials reduce feed consumption andfeed conversion. It seems that neither of the present syntheticanticoccidials is completely satisfactory in controlling coccidiosiseconomic losses and new strategies are urgently required. Diclazuril) on oocyst shedding and their probableeffects on growth performance and feedefficiency of broiler chickens in experimentalcoccidiosis.

کلیدواژه ها:

coccidiosis ، Diclazuril ، Clopidol ، growth performance ، broilers