Cytotoxicity of some 1-(2,4-dihydroxyphenyl)-3-(4-phenylpiperidin-1-yl) prop-2-en-1-one derivatives using MTT assay

Some N-substituted piperidine structures were synthesized and evaluated for cytotoxicity. The N-substituted piperidine with propene substructurecould be considered as a lead structure for furtherstudies of structure activity relationship to develop more potent compounds in future. The compoundswere evaluated against four different cell lines using the standard MTT assay method and doxorubicin was used as the reference drug. The IC50 values weredetermined by constructing dose-response curves and revealed that three of the synthesized compounds were active against breast cancer cell lines. Compound 6a bearing hydroxyl at para position of piperidine ring was the most active compound within this series.

کلیدواژه ها:

Piperidine ، Cytotoxicity ، Breast cancer