Presence of G allele and GG or CG genotype in Vascular Endothelial Growth Factor (VEGF) +405 C/G SNP induce Hypertension

Vascular endothelial growth factor (VEGF) has long been recognized as a hypotensive mediator. However, little is known regarding the contribution of polymorphisms in VEGF gene to essential hypertension (EH), We aimed to investigate the association between +405 VEGF C/G single nucleotide polymorphism (SNP) and occurrence of EH in a population of 100 subjects including 50 normal and 50 patients with Eh. Complications of the hypertension are numerous including visual impairment as important complication and kidney, brain, and heartdamages. Genetic plays a pivotal role in blood pressure regulation; Whereas Hypertension is a multi-factorial and familial condition. In this study were evaluated triglycerid, blood sugar, cholesterol and body mass index of patients. Genotyping of +405 VEGF C/G (rs2010963) SNP was detected using polymerase chain reaction–restriction fragment length polymorphism(RFLP). Genotype frequencies of GG, GC and CC were respectively 44%, 44% and 12% in hypertensive patients and 16%, 34% and 50% in the control group. Allele frequency of G and C were respectively, 66% and 34% of hypertensive patients and 33% and 67% in the control group. In conclusion, +405 VEGF C/G SNP is associated with EH, suggesting presence of G allele and GG or CG genotype confer susceptibility towards EH.

کلیدواژه ها:

polymorphism ، VEGF gene ، hypertension ، single nucleotide polymorphism