Effects of High-Intensity Interval Training and Combined High-Intensity Interval Training Programs on Cancer-Related Fatigue and Cancer Pain

Background: Cancer‑related fatigue and cancer pain are among the most common and debilitating symptoms experienced by individuals undergoing or recovering from cancer treatment. These symptoms significantly impair physical function, psychological well‑being, and overall quality of life. Exercise has emerged as a promising non‑pharmacological intervention for managing cancer‑related symptoms. In particular, high‑intensity interval training (HIIT) and combined HIIT programs that integrate resistance or aerobic training may offer efficient strategies to improve physical capacity and alleviate treatment‑related symptoms in cancer survivors. Methods: This study was conducted as a narrative review of randomized controlled trials and clinical studies examining the effects of HIIT and combined HIIT exercise programs on cancer‑related fatigue and pain. Relevant literature published between ۲۰۰۵ and ۲۰۲۵ was identified through searches of PubMed, Scopus, and Web of Science databases. Eligible studies included adult cancer patients or survivors participating in HIIT‑based interventions or combined programs integrating HIIT with resistance or moderate‑intensity aerobic training. Primary outcomes included changes in cancer‑related fatigue, pain intensity, physical fitness, and quality of life. Results: Evidence from the reviewed studies suggests that HIIT and combined HIIT training programs can significantly reduce cancer‑related fatigue and pain in various cancer populations. These interventions have been associated with improvements in cardiorespiratory fitness, muscular strength, and functional capacity. Combined programs integrating HIIT with resistance training appear particularly effective in enhancing overall physical performance while alleviating symptom burden. Although responses may vary depending on cancer type, treatment stage, and participant characteristics, most studies report good adherence and safety when exercise intensity is appropriately supervised. Conclusion: HIIT and combined HIIT exercise programs appear to be safe and effective strategies for reducing cancer‑related fatigue and pain while improving physical fitness and quality of life in cancer survivors. Incorporating structured high‑intensity exercise into cancer rehabilitation programs may provide meaningful benefits. Future research should focus on identifying optimal training protocols and long‑term effects across different cancer populations.

کلیدواژه ها:

High‑Intensity Interval Training ، Cancer‑Related Fatigue ، Cancer Pain ، Cancer Rehabilitation