Using the proteome method to detect cervical cancer

Cervical cancer is the second leading cause of death among women in developing countries and the seventh in developed countries. Screening in cervical cancer to find genes and proteins that play the role of diagnostic and therapeutic biomarkers is progressing, on the other hand, the molecular mechanism of tumorigenesis is dependent on the protein groups that change in the disease state, so the discovery of these protein groups It seems necessary that the advances in molecular biology in the last decade have helped to raise researchers' understanding of the complex interactions between genetic, transcriptional and translational changes in human cancers. These molecular changes are the basis of effective and growing cancer detection techniques that require microscopic amounts from the patient's sample The present study is a systematic review. In order to find relevant articles in databases, Pubmed, Scopus, Web of Science, in the period from ۲۰۱۶ to ۲۰۲۴, using the keywords proteome, cervical cancer, cervix, and proteomics. Finally, ۱۱ articles were selected according to the objectives of the research. The gene expression pattern of cervical cancer was compared with normal cervical tissue using a microarray containing about ۱۱,۰۰۰ features related to human transcripts with specific function or unknown expressed sequence. were distinguished from cancer samples. Tumors in clinical stages IB and IIB were classified based on the specific expression pattern that provided the possibility of predicting the response of these patients to radiotherapy. These studies have facilitated the understanding of the pathogenesis of cervical cancer. Despite this, many questions remain, such as the transcriptional changes under radiation and the activities of genes that show different expression during cervical cancer treatment. DNA microarray has provided opportunities in the discovery of many genes involved in pathogenesis, susceptibility to disease and differences in response to drugs in women's cancers. Cervical cancer proteomics studies on a large scale based on DNA array and protein have led to the future directions of improving the pathophysiological understanding of cancer. The use of these findings will soon lead to progress in the diagnosis, prognosis and treatment of cancer.

کلیدواژه ها:

proteome ، cervical cancer ، cervix ، proteomics