Bioinformatic identification of products from GIMAP family genes as predictive biomarkers for glioblastoma tumors

Introduction Glioblastoma (GBM) is a subgroup of glioma, a malignant brain tumor with an extremely poor prognosis, representing approximately ۵۷% of all gliomas central nervous system (CNS) tumors. Overall, the prognosis for patients with this disease is poor, with a median survival of less than ۲ years. Therefore, there is a need for more investigation and understanding of the glioblastoma microenvironment. Additionally, there is a lack of reliable biomarkers to predict the response and outcome of current or newly designed therapies. The GTPase IMAP family genes encodes proteins belonging to the immune-associated nucleotide (IAN) subfamily of the GTP-binding superfamily and nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at ۷q۳۶.۱. The GIMAP family genes play a key role in immune function. The correlation of members of the GTPase IMAP family proteins with other cancers, such as cervical and lung cancer has been determined. Members of the GTPase of the immunity‑associated protein (GIMAP) family are important in regulating apoptosis in cancer cells. Dysregulation of GIMAP family gene expression has been observed in several cancers, and some members of this family have been chosen as cancer biomarkers. Materials and Methods In this research, we utilized several databases, including NCBI, GEPIA and PubMed®. We used GEPIA web database to compare gene expression between tumor and paired normal samples, checked the genes and protein symbols on the NCBI server, and used the PubMed resource to search for articles on the status of gene products as biomarkers. Results Among the GIMAP family genes, the expression levels of GIMAP۴, GIMAP۱-GIMAP۵, GIMAP۶, GIMAP۸, and specifically GIMAP۲ were significantly high in glioblastoma tumor tissues. Conclusion In recent years, GIMAP family members have been proposed as biomarkers for several cancers. The significant overexpression of the GIMAP۴, GIMAP۱-GIMAP۵, GIMAP۶, GIMAP۸, and specifically GIMAP۲ genes suggests that their products could potentially be used as biomarkers for GBM.

کلیدواژه ها:

GIMAP family genes ، overexpression ، glioblastoma ، biomarker