Expression alternation and function of long non coding RNAs in larynx cancer

The prevalence and mortality rates associated with laryngeal squamous cell carcinoma (LSCC), a subtype of head and neck squamous cell carcinoma (HNSCC), have shown a consistent annual increase. Despite the implementation of intensive treatment modalities, including surgical intervention, radiotherapy, and chemotherapy, the outlook for patients diagnosed with advanced-stage LSCC remains bleak. While the pathogenesis of LSCC is notably intricate, advancements in molecular profiling may provide insights into its underlying causes. Long non-coding RNAs (lncRNAs) are crucial in the regulation of tumors. Current studies indicate that regulating lncRNAs involves transcription, post-transcriptional modifications, and other mechanisms, highlighting their significant role in tumor biology. Methods: According to the essential role of lncRNAs, we summarized some known lncRNAs and their association with signaling pathways in this study. Results: The prognostic signature associated with the PI۳K/Akt signaling pathway demonstrates a strong predictive capability. The overexpression of MNX۱-AS۱, LINC۰۰۳۳۰, and LSAMP-AS۱ has been shown to enhance the proliferation, migration, and invasion of laryngeal cancer cells, thereby activating p-AKT (Ser۴۷۳) and p-PI۳K. Furthermore, DLEU۲ functions as a competing endogenous RNA, modulating PIK۳CD expression by sequestering miR-۳۰c-۵p, which in turn activates the Akt signaling pathway. Consequently, the lncRNA-DLEU۲/miR-۳۰c-۵p/PIK۳CD/Akt axis presents a potential novel prognostic biomarker and therapeutic target for laryngeal squamous cell carcinomas (LSCCs). In a similar vein, RGMB antisense RNA ۱ (RGMB-AS۱) is found to be upregulated in LSCC samples and correlates with unfavorable clinical outcomes in affected patients. Additionally, RGMB-AS۱ influences LSCC cell proliferation and invasion through the miR-۲۲/NLRP۳ axis. Moreover, IGF۲BP۲-AS۱ exhibits high expression levels in laryngeal cancer cell lines, and its knockdown results in reduced migration and proliferation of TU۶۸۶ laryngeal cancer cells by modulating miR-۳۷۵ expression. The overexpression of PART۱ significantly impacts the proliferation, apoptosis, migration, and invasion of LSCC cells in vitro (P < ۰.۰۰۱), suggesting that PART۱ may play a role in inhibiting the onset and progression of LSCC. Conclusion: In conclusion, the identification of key lncRNAs may reveal new therapeutic targets and prognostic markers for patients with LSCC.

کلیدواژه ها:

laryngeal carcinoma ، lncRNAs ، biomarkers