Introduction: This study endeavors to delineate the variances in pharmacokinetic impacts between the co- administration of Atropine with
Succinylcholine and
Fentanyl versus Atropine paired with
Propofol within the context of sedating infants afflicted with respiratory distress syndrome (RDS) preceding intubation.Methodology: The methodology encompasses a comprehensive spectrum, spanning patient selection criteria, meticulous drug administration protocols, vigilant monitoring of vital signs, systematic blood sampling procedures, precise analytical methodologies, meticulous data analysis techniques, and steadfast adherence to ethical considerations.
Succinylcholine was uniformly administered to infants aged over ۳۴ weeks and selectively to those under ۳۴ weeks based on the attending physician’s discretion. The minimum dosages were set at ۰.۱ mg for both Atropine and Fentanyl, ۲ mg/kg for
Succinylcholine and
Propofol infusion rate ranging from ۰.۱۲۵ to ۰.۳ mg/kg per minute.Findings: Noteworthy reductions in parameters of respiratory distress, including heart rate and respiratory rate, were consistently obsereved following
Fentanyl administration across varying dosage ranges. A targeted serum
Fentanyl concentration of ۰.۴-۰.۶ ng/ml consistently elicited optimal analgesic and sedative effects in neonates.Atropine played a pivotal role in mitigating potential bradycardic effects associated with medications such as Succinylcholine. Promising outcomes were noted with the administration of Atropine concurrently with
Succinylcholine and Fentanyl, potentially optimizing intubation conditions and minimizing attempts required, while the Atropine-
Propofol combination posed inherent risks of precipitating hypotensive episodes.Conclusion: The judicious selection between administering Atropine alongside
Succinylcholine and
Fentanyl versus Atropine-Propofol hinges upon multifaceted considerations pertaining to hemodynamics, duration of action, and potential complications.Tailoring sedative regiments to the specific clinical context and individual patient characteristics is imperative to ensure the attainment of optimal sedation levels and mitigate potential risks during the intubation process.
