The role of noncoding RNAs as an important factor in the incidence and progression of Schizophrenia

Schizophrenia is associated with extensive changes and abnormalities in transcription, expression, and protein production. These changes in noncoding RNA occur in different parts of the brain and change as the disease progresses.Increasing studies in this area show changes in noncoding RNA in people with schizophrenia, including altering MciroRNA expression in the brain of people with schizophrenia. Conclusion There is evidence of alterations in the expression of other noncoding RNAs, including CircRNA, suggesting that circRNAs can interact with RNA-binding proteins (RBPs) and directly or indirectly express gene expression during various processes. Cell-altering Incomplete expression of circRNAs can cause a set of events in the genetic regulatory network. RNA (LncRNAs) are long coding cells involved in the development of different parts of the brain, the specificity and differentiation of oligodendrocyte traces, and final myelination. LncRNA is also involved in regulating vital brain functions, including the maintenance of nerve stem cells, neurogenesis and gliogenesis, homeostasis, and synaptic connections. Are associated with biological brain processes such as hippocampal evolution and aging. In addition, some recent studies have shown that other noncoding RNAs, including short coding RNAs (SnoRNAs), may be affected in schizophrenia. . This review study examines the importance and involvement of noncoding RNA types in the development and progression of schizophrenia.Because the main goal of psychiatric research in this field is clinical identification to detect schizophrenia early and to predict treatment response and risk of side effects, understanding these changes in noncoding RNA can be effective in the prognosis and treatment of schizophrenia.

کلیدواژه ها:

schizophrenia ، noncoding RNA ، microRNA ، lncRNA ، snoRNA ، circRNA ، biomarkers