Methods of Inducing Breast Cancer in Animal Models: A Systematic Review

Introduction & Aim: Breast cancer is the second leading cause of death and the most common cancer in women. Experimental studies of this disease are not possible in humans and there is always the need to develop experimental animal models. The purpose of this study was to investigate the development of breast cancer in laboratory animals. Methods: This systematic review was conducted based on the PRISMA checklist. Articles were extracted with selected keywords from the PubMed, SID, Springer, Medlib and Since- Direct databases without any language restrictions. ۴۵۰ articles were identified and after removal of unrelated or repetitive articles, ۱۵۸ articles were selected. Results: Breast cancer induction models include the use of chemical compounds, transgenic animals, ionizing radiation, and tumor cell transplantation. Tumor chemical compounds usually have advantages such as easy to use and controllable, disadvantages such as high toxicity to humans, tissue constraints and tumors in other tissues. The use of ionizing radiation is also dangerous, and its benefits can be accelerated by induction of tumor, low cost and easy to use. Other methods include the transplantation of cultured cells and transgenic animals, in which there are no hazards of prior methods, but there are some disadvantages such as their time and cost. Conclusion: The presented animal models have both advantages and disadvantages. None of them are absolutely ideal while they are chosen according to the purpose of the investigator and the advantages of each method for cancer researches.

کلیدواژه ها:

Breast Cancer ، Animal Model ، Induced Cancer